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Figure 1�figure supplement 3. The disordered nature of the region between K21 and G37 results in weak density in the cryo-EM map, and makes accurate model building in this region difficult. Shahmoradian et al. Exogenous alpha-synuclein fibrils seed the formation of lewy body-like intracellular inclusions in cultured cells. D and E Rainbow rendering views of the secondary structure elements in five successive rungs of both polymorphs.
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